ANTIMYCOTIC ACTIVITY IN FIXED AND ESSENTIAL OILS
By trial and experience man has identified a number of compounds around him and using them for cure of certain illnesses. Amongst these toxicological properties of certain oils and fatty acids have received a considerable attention over a period of 100 years. Clark first noted antimycotic properties of fatty acids and Kiessel reported that the antifungal property of an oil is increased with an increase in the fatty acid chain length. Later, studies by Linderberg and Linderberg supported the above view. The antimycotic nature of certain fatty acids and their wide occurrence particularly in the preening glands in birds and sebaceous glands in human beings have prompted interest in using oils and fats as natural antimicrobial agents. Kitajima and Kawamura reported that unsaturated fatty acids are more inhibitory to fungi than their corresponding saturated fatty acids. While Wyss et al. noted an increased inhibitory effect of fatty acids with both chain length and degree of saturation.
The wide application of vegetable oils in hair cosmatics could be a possible explanation for this. A number of recent reports including a reviewed information by J.J. Kabara have indicated antimicrobial property in various oils. Jain and Agrawal (1 992) have reported cent per cent inhibition in the spore germination of Aspergillus flavus, Absidia corymbifera, Penicillium nigricans and Candida albicans in the presence of mustard and coconut oils.
Essential oils and perfumes represent another group of oils which are mostly terpenes. Most of them are the secondary metabolites or by products of plant metabolism. The importance of these compounds was well recognised even in the ancient time. Our record shows that the studies on germicidal properties in essential oils were started in the second decade of present century as is evident from the publications made by De and Subramanayam. Since then a number of reports have appeared on the antimicrobial and antifungal properties of essential oils of various plants. Besides these some of reports have indicated inhibitory properties of some essential oils against dermatophytes and related keratinophilic fungi. Jain and Agrawal (1978) reported very high antifungal activity in the essential oils of Amomum subutatum against some keratinophilic fungi. Goutam et al. tested antimycotic properties of the essential oils of Angelica archangelica, Artemisia vestita, Mentha arvensis and Mentha piperita against six strains of Nannizzia (member of Microsporum gypseum complex) and found a variety of responses of these fungi against test oils. There are several other reports which indicate that the essential oils from different plants differ in their toxicity against different test fungi. A well planned screening programme to test antimicrobial and antifungal properties in the essential oils of different plants can be of much help to develop certain chemotherapeutants for the control of fungal diseases in men and animals.
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